8-MA-CAMP SODIUM SALT
8-MA-CAMP SODIUM SALT Basic information
- Product Name:
- 8-MA-CAMP SODIUM SALT
- Synonyms:
-
- 8-MA-CAMP SODIUM SALT
- 8-METHYLAMINOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- 8-methylaminoadenosine-3’,5’cyclicmonophosphate(8-ma-camp),sodiumsalt
- 8-MA-CAMP
- 8-METHYLAMINOADENOSINE 3':5'-CYCLIC MONO PHOSPHATE
- 8-Methylaminoadenosine-3'',5''-cyclic monophosphoric acid sodium salt
- 8-(METHYLAMINO)-ADENOSINE-3'',5''-CYCLIC-MONOPHOSPHORIC ACID CRYSTALLINE
- Adenosine, 8-(methylamino)-, cyclic 3',5'-(hydrogen phosphate)
- CAS:
- 33823-18-6
- MF:
- C11H15N6O6P
- MW:
- 358.25
- Mol File:
- 33823-18-6.mol
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8-MA-CAMP SODIUM SALT Chemical Properties
- Boiling point:
- 707.0±70.0 °C(Predicted)
- Density
- 2.34±0.1 g/cm3(Predicted)
- storage temp.
- −70°C
- solubility
- H2O: freely soluble
- form
- solid
- pka
- 1.00±0.60(Predicted)
- color
- white
MSDS
- Language:English Provider:SigmaAldrich
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8-MA-CAMP SODIUM SALT Usage And Synthesis
Uses
8-MA-cAMP (8-Methylamino-cAMP) is a cyclic AMP analog that acts as a site-selective PKA agonist with similar affinity for the B site of type I and type II protein kinase A. 8-MA-cAMP is used in conjunction with priming analogs that show site A preference, such as 8-piperidinyl cAMP, to achieve selective stimulation of type I[1].
References
[1] Schwede, et al. 8-Substituted cAMP analogues reveal marked differences in adaptability, hydrogen bonding, and charge accommodation between homologous binding sites (AI/AII and BI/BII) in cAMP kinase I and II. Biochemistry 39.30 (2000): 8803-8812. DOI:10.1021/bi000304y
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