4-Phenylthiazole-2-carboxylic acid Chemical Properties

storage temp. 

Sealed in dry,Store in freezer, under -20°C

form 

crystalline powder

color 

White

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HazardClass 

IRRITANT

HS Code 

2934100090

4-Phenylthiazole-2-carboxylic acid Usage And Synthesis

Synthesis

GENERAL METHOD: To a methanolic solution of ethyl 4-phenylthiazole-2-carboxylate (1 equiv.) was slowly added 2N sodium hydroxide solution at room temperature. The reaction mixture was stirred continuously for 4 h. After completion of the reaction, the methanol solvent was removed by rotary evaporator. The residue was adjusted to pH 5-6 with 1N hydrochloric acid solution, at which point the target product 4-phenylthiazole-2-carboxylic acid precipitated as a white solid. The precipitate was collected by filtration and washed with appropriate amount of deionized water and finally dried in a vacuum drying oven to give pure 4-phenylthiazole-2-carboxylic acid (1a-i).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107
[2] Patent: US2018/271846, 2018, A1. Location in patent: Paragraph 0150; 0153; 0154
[3] Patent: US2010/144805, 2010, A1. Location in patent: Page/Page column 45; 46
[4] Patent: US2007/123504, 2007, A1. Location in patent: Page/Page column 24
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 2335 - 2339

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