2,3-DIFLUORO-6-NITROPHENOL Chemical Properties

Melting point:

60-62 °C (lit.)

Boiling point:

215.9±35.0 °C(Predicted)

Density 

1.5200 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

4.77±0.37(Predicted)

color 

White to Light yellow to Green

BRN 

4410368

CAS DataBase Reference

82419-26-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T,Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36-36/37/39

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

IRRITANT, IRRITANT-HARMFUL

HS Code 

29089990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,3-DIFLUORO-6-NITROPHENOL Usage And Synthesis

Chemical Properties

yellow crystals

Uses

2,3-Difluoro-6-nitrophenol was used in the synthesis of 2-methyl-6,7-difluoro-8-oxyquinoline.

Synthesis

a. Add 45.2 g of 2,3,4-trifluoronitrobenzene and 99.5 g of dimethyl sulfoxide (DMSO) to a 1000 mL three-necked flask and stir until completely dissolved. b. Adjust the temperature of the reaction system to 15~17°C, slowly add 125 g of 32% potassium hydroxide (KOH) solution dropwise, and strictly control the temperature during the dropwise addition process. c. Continue to stir the reaction for 3 hours at 15~17°C. d. Upon completion of the reaction, cool the reaction system to 14~16°C, slowly add 290 g of 7.6% potassium hydroxide. e. Add 290 g of 7.6% hydrochloric acid, and slowly add 290 g of 7.6% hydrochloric acid, and stir for 3 hours. -nitrophenol.

References

[1] Patent: US5292967, 1994, A
[2] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 12, p. 4907 - 4913
[3] Patent: US4382892, 1983, A
[4] Patent: CN106632444, 2017, A. Location in patent: Paragraph 0032; 0033; 0034; 0035; 0036; 0037; 0038-0041

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