3-Methyl-4-aminobenzensulfonamide Chemical Properties

Melting point:

174 °C

Boiling point:

409.3±55.0 °C(Predicted)

Density 

1.359±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

10.19±0.60(Predicted)

CAS DataBase Reference

53297-70-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2935909099

3-Methyl-4-aminobenzensulfonamide Usage And Synthesis

Synthesis

N-(2-methyl-4-aminosulfonylphenyl)acetamide (5.1 g, 22.3 mmol) was used as a raw material, which was mixed with 2N hydrochloric acid (76.5 ml) and ethanol (100 ml) and the reaction was carried out at reflux overnight. Upon completion of the reaction, the reaction mixture was neutralized with aqueous sodium carbonate to pH=8. Subsequently, the mixture was extracted with ethyl acetate (80 mL x 4), the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford 4-amino-3-methylbenzenesulfonamide as a light-colored solid (4.9 g, 100% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 6, p. 2338 - 2342
[2] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 304
[3] Patent: EP1208091, 2006, B1. Location in patent: Page/Page column 8; 21
[4] Collection of Czechoslovak Chemical Communications, 1948, vol. 13, p. 161,165,169
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 5, p. 1175 - 1182

3-Methyl-4-aminobenzensulfonamide(53297-70-4)Related Product Information

• p-Anisidine
• Kresoxim-methyl
• 3-Aminobenzenesulfonamide
• Bensulfuron methyl
• 4-Aminobenzoic acid
• Methyl acetate
• 6-Aminocaproic acid
• METHYL THIOPHENE-2-CARBOXYLATE
• Methylparaben
• 2-Aminobenzenesulfonamide
• Methyl acrylate
• Aniline
• Methyl anthranilate
• Glycine
• Sulfanilic acid
• ALTRENOGEST
• Thiophanate-methyl
• Tris(hydroxymethyl)aminomethane