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Cefaclor monohydrate

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Cefaclor monohydrate Basic information

Product Name:
Cefaclor monohydrate
Synonyms:
  • (7R)-3-Chloro-7-[[(R)-aminophenylacetyl]amino]cepham-3-ene-4-carboxylic acid sodium salt
  • Muco-panoral
  • (6R,7R)-7-[[(2R)-2-amino-2-phenyl-acetyl]amino]-3-chloro-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • (6R,7R)-7-[[(2R)-2-azanyl-2-phenyl-ethanoyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
  • Cefaclor (400 mg)
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 7-[[(2R)-2-aMino-2-phenylacetyl]aMino]-3-chloro-8-oxo-, hydrate (1:1),(6R,7R)-
  • CEFACLOR HYDRATE
CAS:
70356-03-5
MF:
C15H16ClN3O5S
MW:
385.82
EINECS:
641-991-5
Product Categories:
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Chiral Reagents
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Mol File:
70356-03-5.mol
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Cefaclor monohydrate Chemical Properties

Melting point:
>180°C (dec.)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Slightly soluble in water, practically insoluble in methanol and in methylene chloride.
color 
White to Light Beige
CAS DataBase Reference
70356-03-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
42/43-36
Safety Statements 
22-36/37-45
WGK Germany 
2
RTECS 
XI0363000
HS Code 
2941906000
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Cefaclor monohydrate Usage And Synthesis

Description

Cefaclor was found by Eli Lilly & Co. in 1976 in the course of studies on the improvement of synthetic procedures for cephalexin. The intermediates with chlorine at the 3 position of the cephem nucleus have excellent antibacterial activity. Cefaclor was selected from among the various derivatives that differed at the 7 position because of its strong activity and high bioavailability following oral administration.

Chemical Properties

Crystalline Solid

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Uses

Second-generation cephalosporin antibiotic. Antibacterial.

brand name

Ceclor (Lilly); Raniclor (Ranbaxy).

Contact allergens

Cefaclor is a semisynthetic cephalosporin antibiotic, related to cefalexin, and a frequent inducer of serum sickness-like reactions.

Cefaclor monohydrate Preparation Products And Raw materials

Raw materials

Phosphorus pentachlorideAcetamidePhenylacetic acidPeroxyacetic acidN-ChlorosuccinimideMethyl chloroformateOzonePenicillin GCefaclortrans-Methyl crotonate

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Cefaclor monohydrate(70356-03-5)Related Product Information