DIETHYL(3-PYRIDYL)BORANE Chemical Properties

Melting point:

172-175 °C(lit.)

Boiling point:

205.9±22.0 °C(Predicted)

Density 

0.86±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

4.40±0.12(Predicted)

form 

Solid

color 

White to Almost white

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C9H14BN/c1-3-10(4-2)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3

InChIKey

OJKBCQOJVMAHDX-UHFFFAOYSA-N

SMILES

C1=NC=CC=C1B(CC)CC

CAS DataBase Reference

89878-14-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

DIETHYL(3-PYRIDYL)BORANE Usage And Synthesis

Chemical Properties

White to yellow solid

Uses

Reactant for: preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents, N-Methylation reactions of the pyridyl group, Palladium catalyzed amination reactions, intramolecular Heck reactions, Coupling reactions and Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.

Uses

Reactant for:

• Preparation of inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
• N-Methylation reactions of the pyridyl group
• Palladium catalyzed amination reactions
• Intramolecular Heck reactions
• Coupling reactions
• Synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling

Uses

suzuki reaction

reaction suitability

reagent type: reductant

Synthesis

Reaction temperature 0 ~ 5 ??, reaction time 6h, diethylmethoxyborane drop time 30 min, material ratio n (3-bromopyridine): n (diethylmethoxyborane) for 0.9:1.0, material ratio n (isopropylmagnesium chloride): n (diethylmethoxyborane) for 1.0:1.0. In the optimal conditions of the process to produce the product is a white solid, melting point of 172 ~ 175 ??, yield of more than 81%. Under the optimal process conditions, the product is white solid with a melting point of 172??175?? and a yield of more than 81%.

DIETHYL(3-PYRIDYL)BORANE(89878-14-8)Related Product Information

• Polyamide
• Capecitabine
• BOC-Glycine
• Boron
• TRIMETHYLBORON
• DIETHYL(3-PYRIDYL)BORANE
• Abiraterone Impurity 4
• Abiraterone Ethyl Ether
• Dehydroepiandrosterone acetate
• Abiraterone
• ABiraterone impurity 15
• Abiraterone Acetate Dimer Impurity
• (3β)-Androsta-5,16-diene-3,17-diol 3-Acetate 17-(Trifluoromethanesulfonate)
• Abiraterone Related CoMpound 2 (Prasterone Triflate)
• Abiraterone Sulfate
• Dehydroepiandrosterone
• Abiraterone Related Compound 8
• DHEA-S