1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nμ-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-methylphenyl)sulfonyl]hydrazide Chemical Properties

Melting point:

220-224 °C

Boiling point:

507.9±53.0 °C(Predicted)

Density 

1.355±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

6.37±0.50(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37

WGK Germany 

3

1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nμ-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-methylphenyl)sulfonyl]hydrazide Usage And Synthesis

Synthesis

Example 6 - Preparation of N,N'-bis(p-toluenesulfonyl)hydrazine: To a solution of dichloromethane (50 mL) containing p-toluenesulfonylhydrazine (9.32 g, 50 mmol) and p-toluenesulfonyl chloride (14.3 g, 75 mmol) was added pyridine (6 mL, 75 mmol). The reaction mixture was stirred at room temperature for 1.5 hours. Subsequently, ether (200 mL) and water (100 mL) were added and stirring was continued at 0°C for 15 minutes. After completion of the reaction, the mixture was filtered and the solid product was washed with ether. Finally, purification by recrystallization from methanol afforded N,N'-bis(p-toluenesulfonyl)hydrazine as a white solid (11.5 g, 68% yield).

References

[1] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1407 - 1413
[2] Chemical Communications, 2017, vol. 53, # 54, p. 7485 - 7488
[3] Organic Letters, 2007, vol. 9, # 16, p. 3195 - 3197
[4] Chemical Communications, 2018, vol. 54, # 28, p. 3516 - 3519
[5] Liebigs Annalen der Chemie, 1991, # 10, p. 983 - 986

1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nμ-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-methylphenyl)sulfonyl]hydrazide(14062-05-6)Related Product Information

• Tosyl chloride
• 1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nμ-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-methylphenyl)sulfonyl]hydrazide
• 4-Methylbenzenesulfonhydrazide
• METHANESULFONYL HYDRAZIDE
• Benzenesulfonyl hydrazide