4-IODOBUTYL ACETATE Chemical Properties

Boiling point:

94-95 °C5.5 mm Hg(lit.)

Density 

1.61 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.497(lit.)

Flash point:

195 °F

solubility 

Difficult to mix.

form 

liquid

color 

Light green turbid

Sensitive 

Light Sensitive

CAS DataBase Reference

40596-44-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

HS Code 

29153900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

4-IODOBUTYL ACETATE Usage And Synthesis

Chemical Properties

CLEAR DARK BROWN LIQUID

Uses

4-Iodobutyl acetate is used in the preparation of tricyclohexyl(acetoxybutyl))phosphonium iodide, tri-n-hexyl(acetoxybutyl))phosphonium iodide

Synthesis Reference(s)

Synthetic Communications, 24, p. 951, 1994 DOI: 10.1080/00397919408020770

Synthesis

The synthesis of 4-IODOBUTYL ACETATE is as follows:Acetic acid (0.30mmol, 1.0 equivalent), CuI (0.03mmol, 10.0mol%, 5.7mg) and NaI (0.60mmol, 2.0 equivalent, 89.9mg) were added to a 10mL Schlenk tube equipped with a magnetic stirring device. Vacuum the flask with a pump and backfill it three times with nitrogen. Then, 1.0 mL tetrahydrofuran (12.30 mmol, 41.0 equivalence, 1 mL, c=0.30 M), deionized water (0.45 mmol, 1.5 equivalence) and TMSCF3 (0.36 mmol, 1.2 equivalence) were added under N2 atmosphere. The mixture is stirred at 150°C (thermostatic oil bath pot) for 12 hours. After cooling to room temperature, dilute the mixture with ethyl acetate (15 mL), wash with water and brine, and dry on anhydrousNa2SO4. After Extraction by EtOAc (5 mL x 3), the combined organic layer was dehydrated with anhydrousNa2SO4 and concentrated under reduced pressure. The crude product is purified by rapid chromatography on silica gel to obtain alkyl iodide.

4-IODOBUTYL ACETATE(40596-44-9)Related Product Information

• 2-iodo-1-ethanol acetate
• 3-iodo-1-propanol acetate
• 5-iodo-1-pentanol acetate
• 6-Iodo-1-Hexanol
• 5-Chloropentanol
• 6-Chlorohexanol
• 3-Bromo-1-propanol
• 6-iodo-1-hexanol acetate
• 8-iodo-1-octanol acetate
• 9-iodo-1-nonanol acetate
• 7-iodo-1-heptanol acetate
• 10-iodo-1-nonanol acetate
• 2-(acetoxymethyl)-4-iodobutyl acetate
• 4-IODOBUTYL ACETATE
• 1,2,3-TRI-O-BENZOYL-4-DEOXY-ALPHA-L-FUCOPYRANOSE
• 4-IODOBUTYL BENZOATE
• 8-(IODOMETHYL)-1,8-DIMETHYL-3-OXABICYCLO[3.2.1]OCTANE-2,4-DIONE
• 2,3,5-TRI(ACETYLOXY)-6-(IODOMETHYL)TETRAHYDRO-2H-PYRAN-4-YL ACETATE