2-PIPERIDYLMETHYLAMINE Chemical Properties

Boiling point:

63-66°C/12mm

Density 

0.9406 g/mL at 25 °C

refractive index 

1.4850

Flash point:

63-66°C/12mm

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

10.32±0.29(Predicted)

color 

Clear Colorless

BRN 

102994

InChIKey

RHPBLLCTOLJFPH-UHFFFAOYSA-N

CAS DataBase Reference

22990-77-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

2735

WGK Germany 

2

HazardClass 

8

PackingGroup 

III

HS Code 

29333990

2-PIPERIDYLMETHYLAMINE Usage And Synthesis

Uses

Reactant for reversible aminal formation

Reactant for synthesis of:

• Annulated N-heterocyclic carbene ligands
• M3 Muscarinic receptor antagonists
• Selective 5-ht5A receptor antagonists
• Ternary platinum(II) complexes

Uses

2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.

Purification Methods

Dry (over Na2SO4) and distil the piperidine under vacuum from KOH. It has been purified via the Reinekate salt (m 173-174o) and its dipicrate salt (m 201o, from H2O). [Norton et al. J Am Chem Soc 68 1330 1946, Mortimer Aust J Chem 11 84 1958, Augustine J Am Chem Soc 81 4667 1959, Beilstein 22 III/IV 3765.]

2-PIPERIDYLMETHYLAMINE(22990-77-8)Related Product Information

• Mepivacaine
• FLECAINIDE ACETATE
• Ropivacaine
• Bupivacaine
• AJMALINE
• 2-PIPERIDYLMETHYLAMINE
• Mepivacaine hydrochloride
• Bupivacaine hydrochloride
• VERRUCULOGEN
• 2-ACETAMIDO-1,2,5-TRIDEOXY-1,5-IMINO-D-G LUCITOL
• D-PHE-PIP-ARG-PNA
• (S)-N-Boc-3-aminomethylpiperidine
• 1-N-Cbz-4-N-(Boc-aminomethyl)piperidine
• 2-(Boc-aminomethyl)-piperidine
• (Cbz-4-aminomethyl)piperidine, min. 95 %
• 3-(Aminomethyl)-1-methylpiperidine
• 4-(Boc-Aminomethyl)piperidine
• (R)-2-AMINOMETHYL-1-N-BOC-PIPERIDINE