1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Basic information
- Product Name:
- 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione
- Synonyms:
-
- 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione
- A-39183B
- Antibiotic A-39183B
- Setomimycin
- SetoMiMycin [SetoMiMicin]
- AM 2947
- AM2947
- AM-2947
- CAS:
- 69431-87-4
- MF:
- C34H28O9
- MW:
- 580.58
- Mol File:
- 69431-87-4.mol
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1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Chemical Properties
- Boiling point:
- 765.2±60.0 °C(Predicted)
- Density
- 1.479±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Chloroform: soluble; DMSO: soluble
- form
- A solid
- pka
- 3.61±0.60(Predicted)
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1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Usage And Synthesis
Uses
Setomimycin is a rare 9,9’-bianthryl antibiotic first isolated from a strain of Streptomyces pseudovenezuelae by Omura and colleagues at the Kitasato Institute, Japan, in 1978. Setomimycin is active against Gram positive bacteria, including mycobacteria, and has antitumor activity both in vitro and in vivo. Limited access has restricted further research on this metabolite.
Uses
Setomimycin is an antibiotic that is active against Gram positive bacteria, including mycobacteria.
in vivo
Setomimycin (20 mg/kg; i.p.; alternate days for two weeks) shows antitumor activity in mice[2].
Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].
| Pharmacokinetic parameters | Value |
| Cmax (ng/ml) | 694 ± 62 |
| Tmax (h) | 0.3 ± 0.1 |
| T1/2 (h) | 2.3 ± 0.5 |
| AUC0-t (ng.h/mL) | 2613 ± 111 |
| AUC0-α (ng.h/mL) | 2734 ± 108 |
| Vd (L/Kg) | 24 ± 4 |
| Cl (L/h/Kg) | 7.4 ± 0.3 |
| Animal Model: | 6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2] |
| Dosage: | 20 mg/kg |
| Administration: | I.p.; every other day for two weeks |
| Result: | Decreased primary tumor weight (76%) and volume (90.5%). |
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dioneSupplier
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