Prostaglandin A2-d4 Chemical Properties

solubility 

DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1)

Prostaglandin A2-d4 Usage And Synthesis

Uses

Prostaglandin A2-d4 (PGA2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGA2 by GC- or LC- mass spectrometry. PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. It has low biological potency in most bioassays, but does show some antiviral/antitumor activity. At a 25 μM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase. It has also been shown to act as a vasodilator with natriuretic properties.

Definition

ChEBI: Prostaglandin A2-d4 is an organic molecular entity.