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Glycine hydrochloride

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Glycine hydrochloride Basic information

Product Name:
Glycine hydrochloride
Synonyms:
  • h-gly-oh.hcl
  • GLYCINE HYDROCHLORIDE SOLUTION
  • Aminoaceticacid.HCl=H-Gly-OH.HCl
  • Glycinehydrochloride,98%
  • Glycine hydrochloride, BR,99%
  • Glycocol hydrochloride
  • Glycine solution hydrochloride
  • Glycine hydrochloride,99%
CAS:
6000-43-7
MF:
C2H6ClNO2
MW:
111.53
EINECS:
227-841-8
Product Categories:
  • food ingredients
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  • Amino Acids, Peptides and Proteins
  • Amino AcidsAnalytical Standards
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  • omega-Aminocarboxylic Acids
  • omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
Mol File:
6000-43-7.mol
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Glycine hydrochloride Chemical Properties

Melting point:
176-180 °C(lit.)
Density 
1.457[at 20℃]
vapor pressure 
0.003Pa at 20℃
storage temp. 
2-8°C
form 
Crystalline Powder
color 
White to almost white
Water Solubility 
SLIGHTLY SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,4491
BRN 
3909617
LogP
-3.25 at 20℃
CAS DataBase Reference
6000-43-7(CAS DataBase Reference)
EPA Substance Registry System
Glycine, hydrochloride (6000-43-7)
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Safety Information

Risk Statements 
22
Safety Statements 
24/25-44
RIDADR 
UN 1789 8/PG 3
WGK Germany 
2
RTECS 
MC0560000
10
TSCA 
Yes
HS Code 
29224999

MSDS

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Glycine hydrochloride Usage And Synthesis

Chemical Properties

white crystals or crystalline powder

Uses

Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Glycine Hydrochloride is commonly used in buffer solutions, in electrophoresis, and preparative chromatography.

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
in the preparation of glycine-HCl buffer
to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
to regenerate the sensor to elute the bound C-reactive protein (CRP)

Definition

Glycine hydrochloride is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.

Preparation

Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle.
synthesis of Glycine hydrochloride

Flammability and Explosibility

Notclassified

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia and reperfusion.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Purification Methods

Crystallise the salt from absolute EtOH or 80% EtOH. Monoglycine hydrochloride has m 176-177o, and diglycine monohydrochloride has m 187o. [Frost J Am Chem Soc 64 1286 1942, Beilstein 4 III 1111, 4 IV 2353.]

Glycine hydrochloride Preparation Products And Raw materials

Preparation Products

Glycine hydrochlorideSupplier

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