8-OH-DPAT·hydrobromide
8-OH-DPAT·hydrobromide Basic information
- Product Name:
- 8-OH-DPAT·hydrobromide
- Synonyms:
-
- 3-(Dipropylamino)tetralin-5-ol·hydrobrominate
- Serotonin agonist DPAT
- rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide
- (+/-)-8-Hydroxy(N,N-dipropyl-2-aMino)tetralin HydrobroMide
- 7-(DipropylaMino)-5,6,7,8-tetrahydro-1-naphthalenol HydrobroMide
- 8-OH-DPAT HRr
- 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
- 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide76135-31-4
- CAS:
- 76135-31-4
- MF:
- C16H25NO.BrH
- MW:
- 328.29
- Product Categories:
-
- Agonist
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 76135-31-4.mol
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8-OH-DPAT·hydrobromide Chemical Properties
- Melting point:
- 221.5-222.0 °C
- storage temp.
- Desiccate at +4°C
- solubility
- Soluble to 20 mM in water with gentle warming
- form
- Powder
- color
- White to off-white
- EPA Substance Registry System
- 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide (1:1) (76135-31-4)
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8-OH-DPAT·hydrobromide Usage And Synthesis
Uses
Dopamine receptor Agonist.
Biological Activity
The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.
in vivo
8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide (32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].
IC 50
5-HT1A Receptor: 8.19 (pIC50)
storage
Desiccate at +4°C
8-OH-DPAT·hydrobromideSupplier
J & K SCIENTIFIC LTD.
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
Nanjing Norris-Pharm Technology Co., Ltd
- Tel
- 18652989687
- sales@norris-pharm.com
DebyeTec.com Inc.
- Tel
- 18-086626237 18086626237
- 2693528373@qq.com
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8-OH-DPAT·hydrobromide(76135-31-4)Related Product Information
- BIS(3-AMINOPROPYL) ETHER
- Ortetamine
- AURORA KA-7111
- 1,2,3,4-Tetrahydro-N-methyl-2-naphthalenamine
- O-desmethylmethoxyphenamine
- 1,2,3,4-TETRAHYDRO-2-NAPHTHYLAMINE
- 2-(2-aminoethyl)phenol
- 5,6,7,8-TETRAHYDRO-1-NAPHTHOL
- (R)-(+)-8-HYDROXY-DPAT HYDROBROMIDE
- S(-)-8-HYDROXY-DPAT HYDROBROMIDE
- 2-(2-aminopropyl)phenol
- 8-OH-DPAT·hydrobromide