4-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE Chemical Properties

Melting point:

189.00°C - 193.00°C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22

HazardClass 

IRRITANT

HS Code 

2933599590

4-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE Usage And Synthesis

Synthesis

GENERAL METHOD: A mixture of 3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one (1 mmol), guanidine nitrate (2 mmol) and anhydrous K2CO3 (5 mmol) in n-butanol (10 mL) was refluxed for 12 hours. After completion of the reaction, it was cooled to room temperature and the reaction solution was poured into water (30 mL) and extracted with ethyl acetate (3 x 20 mL). The organic layers were combined and concentrated under reduced pressure, and the resulting crude product was purified by recrystallization from ether to give 4-(4-methoxyphenyl)pyrimidin-2-amine.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3024 - 3028

4-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE(99844-02-7)Related Product Information

• 4-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE
• 5-(4-methoxyphenyl)pyrimidin-2-amine
• 4-(TRIFLUOROMETHYL)-6-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE
• BUTTPARK 41\09-78
• 5-BROMO-N-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE
• 5-bromo-2-chloro-N-(3-methoxyphenyl)pyrimidin-4-amine
• N-[2-(1H-INDOL-3-YL)ETHYL]-5-(4-METHOXYPHENYL)PYRIMIDIN-2-AMINE
• 4-CHLORO-6-(3-METHOXYPHENYL)PYRIMIDIN-5-AMINE
• 2-CHLORO-N-(3-METHOXYPHENYL)PYRIMIDIN-4-AMINE
• 4-(4-(2-[METHYL(2-PYRIDINYL)AMINO]ETHOXY)PHENYL)-2-PYRIMIDINAMINE
• 4-[2-CHLORO-4-(4-CHLOROPHENOXY)PHENYL]-2-PYRIMIDINAMINE
• 4-(4-METHOXYPHENYL)-N,N-DIMETHYL-5-(METHYLSULFONYL)-2-PYRIMIDINAMINE
• 4-(4-[(2,4-DICHLOROBENZYL)OXY]PHENYL)-2-PYRIMIDINAMINE
• 4-(4-[(2-CHLORO-6-FLUOROBENZYL)OXY]PHENYL)-2-PYRIMIDINAMINE
• 2-(2-AMINO-6-(4-METHOXYPHENYL)PYRIMIDIN-4-YL)-4-METHYLPHENOL
• 4-[4-(3-FLUOROPROPOXY)PHENYL]-2-PYRIMIDINAMINE
• 4,5-BIS(4-METHOXYPHENYL)-2-PYRIMIDINAMINE
• BUTTPARK 41\09-79