Hydrocortisone-17-butyrate Chemical Properties

Melting point:

210.0 to 214.0 °C

Boiling point:

466.2°C (rough estimate)

Density 

1.0914 (rough estimate)

refractive index 

1.4593 (estimate)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

12.98±0.10(Predicted)

form 

Solid

color 

White to Off-White

Merck 

14,4787

InChIKey

BMCQMVFGOVHVNG-IZBZUILHNA-N

SMILES

O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r|

CAS DataBase Reference

13609-67-1(CAS DataBase Reference)

Safety Information

WGK Germany 

2

RTECS 

GM9002000

HS Code 

2937290000

MSDS

• Language:English Provider:SigmaAldrich

Hydrocortisone-17-butyrate Usage And Synthesis

Description

Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].

Uses

Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.

Uses

antineoplastic

Uses

Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.

Definition

ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.

brand name

Locoid (Ferndale); Locoid (Yamanouchi).

Contact allergens

Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti- sone. It represents the D2 group of corticosteroids, non C 16 methylated with a C 17 ester: hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrocortisone aceponate (17-propionate and 21-acetate), methylpred- nisolone aceponate, and prednicarbate. It is sometimes hydrolyzed in vivo into hydrocortisone, giving allergic reactions to group-A-sensitized people.

Biochem/physiol Actions

Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.

References

[1] R N Brogden. “Hydrocortisone 17-butyrate: a new topical corticosteroid preliminary report.” ACS Chemical Neuroscience 12 4 (1976): 249–57.

Hydrocortisone-17-butyrate(13609-67-1)Related Product Information

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