FMRF AMIDE Chemical Properties

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble in DMSO

pka

13.35±0.46(Predicted)

Sequence

Phe-Met-Arg-Phe-NH2

Safety Information

WGK Germany 

3

MSDS

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FMRF AMIDE Usage And Synthesis

Description

FMRFamide (FMRFa) was originally isolated as a cardioacceleratory peptide from mollusks. To date, a number of biologically active FMRFas and their related peptides have been identified. 

Biological functions

Target cells and function The predominant effect of FaRPs is the reduction of spontaneous muscle contractions, such as in the intestinal muscle and the heart rate. Among FaRP subtypes, some FaRPs function in gut contraction and other subtypes do not. Physiological discrimination according to different subtype of FaRPs results in extensive functions.For example, FaRPs exert acceleratory effects on the heart rate, inhibitory effects on gut motility, and modulate synaptic activity. Furthermore, sequential ecdysis behavior is also regulated by FaRPs, consequently activating the downstream of the eclosion hormone (EH) and ecdysistriggering hormone (ETH).During ecdysis, FaRP-expressing Tv neurons are activated by ETH.

Synthesis

Gene, mRNA, and precursor D. melanogaster FMRFa mRNA produces a deduced prepropeptide composed of 347 aa. The prepropeptide is composed of a signal sequence, and 10 copies of FMRFa and extended FaRPs. The mature peptides are processed proteolytically and amidated at each C-terminal of the peptides.

Uses

Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.

in vivo

References

[1] Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. DOI:10.1085/jgp.110.5.611
[2] Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. DOI:10.1016/0196-9781(84)90021-4
[3] Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. DOI:10.1016/0143-4179(87)90054-0

FMRF AMIDE(64190-70-1)Related Product Information

• [D-MET2]-FMRF-AMIDE
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• FMRF amide (Phe-Met-Arg-Phe-NH2) (Molluscan Cardioexcitatory Neuropeptide)
• FMRF amide [D-Phe1] (D-Phe-Met-Arg-Phe-NH2)
• FMRF amide [D-Met2] (Phe-D-Met-Arg-Phe-NH2)
• FMRF amide-like Peptide I (lobster) (Ser-Asp-Arg-Asn-Phe-Leu-Arg-Phe-NH2)
• FMRF AMIDE MOLLUSCAN CARDIOEXCITATORY PEPTIDE,FMRF-AMIDE 1 1/2ACOH 2H2O,FMRF AMIDE
• FMRF AMIDE-LIKE PEPTIDE II, LOBSTER
• FMRF amide [D-Arg3] (Phe-Met-D-Arg-Phe-NH2)
• FMRF amide [D-Phe4] (Phe-Met-Arg-D-Phe-NH2)
• FMRF-AMIDE LIKE PEPTIDE 1 (LOBSTER),FMRF AMIDE-LIKE PEPTIDE I, LOBSTER
• FMRF amide (Nle-Arg-Phe-NH2)
• FMRF amide (Leu-Ser-Ser-Phe-Val-Arg-Ile-NH2)
• FMRF amide (Phe-Leu-Arg-Arg)
• FMRF amide (Tyr-Phe-Met-Arg-Phe-NH2)
• FMRF amide (Trp-Nle-Arg-Phe-NH2)
• FMRF amide (Met-Arg-Phe)