Basic information Description Biological functions Synthesis Safety Supplier Related
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FMRF AMIDE

Basic information Description Biological functions Synthesis Safety Supplier Related

FMRF AMIDE Basic information

Product Name:
FMRF AMIDE
Synonyms:
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE
  • MOLLUSCAN CARDIOEXCITATORY NEUROPEPTIDE 1 1/2 ACOH 2H2O
  • MOLLUSCAN CARDIOEXCITATORY PEPTIDE
  • PHE-MET-ARG-PHE AMIDE
  • PHE-MET-ARG-PHE-NH2
  • PHE-MET-ARG-PHE-NH2 1/2ACOH 2H2O
  • 6-O-?D-Glucopyranosyl-D-glucitol
  • L-PHENYLALANYL-L-METHIONYL-L-ARGINYL-L-PHENYLALANINAMIDE)
CAS:
64190-70-1
MF:
C29H42N8O4S
MW:
598.76
Mol File:
64190-70-1.mol
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FMRF AMIDE Chemical Properties

Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in DMSO
pka
13.35±0.46(Predicted)
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Safety Information

WGK Germany 
3

MSDS

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FMRF AMIDE Usage And Synthesis

Description

FMRFamide (FMRFa) was originally isolated as a cardioacceleratory peptide from mollusks. To date, a number of biologically active FMRFas and their related peptides have been identified. 

Biological functions

Target cells and function The predominant effect of FaRPs is the reduction of spontaneous muscle contractions, such as in the intestinal muscle and the heart rate. Among FaRP subtypes, some FaRPs function in gut contraction and other subtypes do not. Physiological discrimination according to different subtype of FaRPs results in extensive functions.For example, FaRPs exert acceleratory effects on the heart rate, inhibitory effects on gut motility, and modulate synaptic activity. Furthermore, sequential ecdysis behavior is also regulated by FaRPs, consequently activating the downstream of the eclosion hormone (EH) and ecdysistriggering hormone (ETH).During ecdysis, FaRP-expressing Tv neurons are activated by ETH.

Synthesis

Gene, mRNA, and precursor D. melanogaster FMRFa mRNA produces a deduced prepropeptide composed of 347 aa. The prepropeptide is composed of a signal sequence, and 10 copies of FMRFa and extended FaRPs. The mature peptides are processed proteolytically and amidated at each C-terminal of the peptides.

FMRF AMIDESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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Watson Biotechnology Co.,Ltd
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027-027-59207879 18140587686
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Creative Peptides
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Codow Chemical Co.,Ltd.
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18620099427
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