Phthalan Chemical Properties

Melting point:

6°C

Boiling point:

192 °C (lit.)

Density 

1.098 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.546(lit.)

Flash point:

146 °F

solubility 

Low aqueous solubility.

form 

Liquid

color 

Colorless to Almost colorless

BRN 

111932

InChI

1S/C8H8O/c1-2-4-8-6-9-5-7(8)3-1/h1-4H,5-6H2

InChIKey

SFLGSKRGOWRGBR-UHFFFAOYSA-N

SMILES

C1OCc2ccccc12

CAS DataBase Reference

496-14-0(CAS DataBase Reference)

NIST Chemistry Reference

Phthalan(496-14-0)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25-3/9/49

WGK Germany 

3

HS Code 

29321900

Storage Class

10 - Combustible liquids

MSDS

• Language:English Provider:1,3-Dihydroisobenzofuran
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Phthalan Usage And Synthesis

Chemical Properties

clear colourless to slightly yellow liquid

Uses

Phthalan s a benzofuran compound participating in a variety of organic reactions. It is used in the arylation of tetrahydroquinolines and isochromans, as well as the oxidation and amination of benzylic sp3 C-H bonds.

Synthesis

Et3SiH (4 equiv) was added to a stirred solution of 2-hydroxychalcone derivative (0.5 mmol, 1 equiv) and InCl3 (0.5 ) in anhydrous acetonitrile (2.5 mL). equiv) in a stirred solution in anhydrous acetonitrile (2.5 mL). Reflow the reaction mixture. Add water to the reaction mixture. Extract the reaction mixture with dichloromethane. Wash the combined organic layers with brine. Dry the combined organic layers with anhydrous Na 2 SO 4 . Concentrate the layers under vacuum. The reaction was carried out by silica gel column chromatography (petroleum ether/ethyl acetate = The resulting solution was purified by silica gel column chromatography (petroleum ether/ethyl acetate= 50:1) to afford 1,3-dihydroisobenzofuran.

Phthalan(496-14-0)Related Product Information

• Potassium hydrogen phthalate
• Tetrahydrofuran
• Iron oxide
• Lithium oxide
• NITRIC OXIDE
• 1'-Acetonaphthone
• Benzofuran
• Zinc oxide
• Sodium oxide
• Dihydromyrcenol
• 2,3-Dihydrobenzofuran
• ETHYLENE OXIDE
• Aluminum oxide
• (Diethoxymethyl)diphenylphosphine oxide
• NITROUS OXIDE
• 6-Aminofluorescein
• 4',5'-DIBROMOFLUORESCEIN
• ERYTHROSIN B