Z-VAL-OSU Chemical Properties

Melting point:

114-118℃

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Soluble in 1mmol in 2mL DCM.

pka

10.51±0.46(Predicted)

form 

Powder

color 

White to off-white

optical activity

-21.534°(C=0.01 g/ml Dioxane)

CAS DataBase Reference

3496-11-5

Safety Information

HS Code 

2933.79.8500

Z-VAL-OSU Usage And Synthesis

Chemical Properties

White to off- white powder

Uses

N-Benzyloxycarbonyl-L-valine N-succinimidyl ester, is an amino acid which is widely used in pharmaceutical and food industry.

Synthesis

Step 1. To a stirred solution of N-hydroxybutanediimide (1 g, 4 mmol) and CBZ-L-valine (459 mg, 4 mmol) in tetrahydrofuran (THF, 20 mL) was added N,N'-dicyclohexylcarbodiimide (DCC, 908 mg, 4.4 mmol) at 0° C. The reaction was carried out at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated to afford (S)-2,5-dioxopyrrolidin-1-yl 2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate (yield: 90%).

References

[1] Chemical Communications, 2015, vol. 51, # 67, p. 13213 - 13216
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 28, p. 7736 - 7749
[3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 133
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 989 - 1000
[5] Journal of the American Chemical Society, 2003, vol. 125, # 22, p. 6677 - 6686

Z-VAL-OSU(3496-11-5)Related Product Information

• N-Carbobenzyloxy-L-valine
• Z-VAL-OET
• CBZ-L-VALINE METHYL ESTER
• Z-VAL-GLY-OH
• Z-VAL-ALA-OH
• Z-VAL-ONP
• Z-VAL-NH2
• Z-VAL-PRO-OH
• Z-VAL-PHE-OH
• Z-TYR-OH
• Z-VAL-PHE-OME
• Z-TLE-OH DCHA
• Z-TRP-OME
• Z-TYR(TBU)-OSU
• Z-TYR-ONP
• Z-TYR-OME
• Zuclopenthixol
• Z-L-Valine NCA