PROSTAGLANDIN F1ALPHA Chemical Properties

Melting point:

102.5°C

Boiling point:

409.31°C (rough estimate)

alpha 

+24°(D/24℃)(c=0.87,THF)

Density 

1.0321 (rough estimate)

refractive index 

1.6120 (estimate)

storage temp. 

-20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 2 mg/ml

form 

A crystalline solid

pka

4.78±0.10(Predicted)

BRN 

2704846

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

RTECS 

GY4569700

F 

8-10

MSDS

• Language:English Provider:SigmaAldrich

PROSTAGLANDIN F1ALPHA Usage And Synthesis

Description

Prostaglandin F_1α (PGF_1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF_1α and PGF_2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10⁻¹¹ M. PGF_1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF_2α. It is only half as active as PGF_2α in inducing human respiratory smooth muscle contractions in vitro.

Description

Prostaglandin F_1α (PGF_1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF_1α and PGF_2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10⁻¹¹ M. PGF_1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF_2α. It is only half as active as PGF_2α in inducing human respiratory smooth muscle contractions in vitro.

PGF_1α MaxSpec^® standard is a quantitative grade standard of PGF_1α that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGF_1α MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Uses

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10?11 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.

Uses

PGF1alpha (Prostaglandin F1alpha) is a smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2).

Definition

ChEBI: Prostaglandin F1alpha is a prostaglandins Falpha. It has a role as a human metabolite.

General Description

Prostaglandins (PGs) contain prostanoic acid. They are divided as PGA, PGB, PGC, PGD, PGE and PGF groups. They all contain a five-member ring structure differing in their functions. PGF is known to be more soluble in phosphate buffer. PGF1α is a serum eicosanoid.

Biochem/physiol Actions

PGs mediate vasodilation and vasoconstriction.

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