1,3-PROPANEDISULFONIC ACID DISODIUM SALT Chemical Properties

Melting point:

>300°C

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Almost white

Water Solubility 

Partially soluble in cold water, hot water.

Sensitive 

Hygroscopic

BRN 

3767479

CAS DataBase Reference

36589-58-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29041000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,3-PROPANEDISULFONIC ACID DISODIUM SALT Usage And Synthesis

Chemical Properties

White coarse powder

Uses

keratolytic

Uses

It is used as a reactant involved in synthesis of cadmium(II) bipyridine complex metal-organic frameworks with alkanedisulfonates, alkylenedisulfonate inorganic-organic hybrid materials and glycosaminoglycan mimetic involved in pharmacological studies for the treatment of amyloid A amyloidosis.

Uses

Reactant involved in synthesis of:

• Cadmium(II) bipyridine complex metal-organic frameworks with alkanedisulfonates
• Alkylenedisulfonate inorganic-organic hybrid materials

Glycosaminoglycan mimetic involved in pharmacological studies for the treatment of amyloid A amyloidosis

Synthesis

Step 3: To a methanolic (15 mL) suspension of the disulfone compound (0.62 g, 2.23 mmol) obtained in Step 2, a methanolic solution of 0.5 M sodium methanol (8.9 mL, 4.58 mmol) was slowly added. The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the homogeneous reaction solution was concentrated under reduced pressure to give a solid. The solid was suspended in ethanol (20 mL) and stirred at room temperature for 1 hour. Subsequently, the solid was separated by filtration and the filter cake was washed sequentially with ethanol (2 x 10 mL) and ether (2 x 10 mL). The resulting solid was dissolved in water (2 mL) and purified by passing through a C8 reversed-phase silica gel pad, using water as eluent. The eluate containing sodium 1,3-propanedisulfonate (P1, disodium salt) was collected and lyophilized to give sodium 1,3-propanedisulfonate (0.41 g, 85% yield) in white solid form. The structure of the product was confirmed by 1H NMR (D2O, 500 MHz): δ 1.84 (quintuple peak, J = 8.0 Hz, 2H), 2.44 (triple peak, J = 8.0 Hz, 4H).

References

[1] Patent: WO2011/17800, 2011, A1. Location in patent: Page/Page column 100

1,3-PROPANEDISULFONIC ACID DISODIUM SALT(36589-58-9)Related Product Information

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