tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Chemical Properties

Melting point:

206 °C (dec.)(lit.)

alpha 

86 º (c=5.5 in methylene chloride)

Boiling point:

509.6±50.0 °C(Predicted)

Density 

1.175±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-3.28±0.60(Predicted)

optical activity

[α]20/D +86°, c = 5.5 in methylene chloride

InChIKey

MRUKRSQUUNYOFK-MOPGFXCFSA-N

CAS DataBase Reference

112741-50-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Usage And Synthesis

Uses

(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine (Williams chiral auxiliary) can be used as a reactant:

• In the asymmetric synthesis of cylindrospermopsin and related alkaloids via an intramolecular 1,3-dipolar cycloaddition reaction.
• To synthesize boc-3-(1-methylcyclopropyl)-D-alanine, which is used as an intermediate to prepare 4-fluoroproline-based analogs as potent tripeptide thrombin inhibitors.
• In the total synthesis of potent hepatotoxic alkaloid 7-epicylindrospermopsin by intramolecular 1,3-dipolar cycloaddition and nitroaldol reaction.
• To prepare differentially functionalized diaminoglutamic acids via radical reaction of selenide with methyl 2-acetamidoacrylate.

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate(112741-50-1)Related Product Information

• tert-Butanol
• Cyhalofop-butyl
• Buprofezin
• Tridemorph
• 2-Butoxyethanol
• Diethylene glycol monobutyl ether
• Dimethomorph
• Moroxydine hydrochloride
• tert-Butyl peroxyacetate
• tert-Butyl acetate
• Biphenyl
• Butyl acrylate
• Butyl acetate
• Moroxydine
• Phenmetrazine
• (5R,6S)-5,6-Diphenyl-2-morpholinone
• 3-methylmorpholine
• (S)-2-Methyl-morpholine