tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate CAS#: 112741-50-1

ChemicalBook > Product Catalog > Organic Chemistry > Carboxylic acids and derivatives > tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

Basic information Safety Supplier Related

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Basic information

Product Name:

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate

Synonyms:

(2S,3R)-6-Oxo-2,3-diphenyl-morpholine-4-carboxylic acid tert-butyl ester
(5S,6R)-(+)-4-Boc-5,6-diphenyl-2-Morpholinone, 99%
(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylMorpholine
(5R,6S)-N-Boc-5,6-diphenyl-2-morpholinone
tert-butyl (2S,3R)-6-oxo-2,3-diphenylMorpholine-4-carboxylate
(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylMorpholine
(2S, 3R) - (+) - N- t-butoxycarbonyl-6-oxo-2,3-diphenyl-Morpholine
(2S,3R)-tert-Butyl

CAS:

112741-50-1

MF:

C21H23NO4

MW:

353.41

EINECS:

627-150-5

Product Categories:

Chiral Building Blocks
Heterocyclic Building Blocks
Morpholines
API intermediates

Mol File:

112741-50-1.mol

Less

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Chemical Properties

Melting point:: 206 °C (dec.)(lit.)
Boiling point:: 509.6±50.0 °C(Predicted)
alpha: 86 º (c=5.5 in methylene chloride)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in THF, CH2Cl2
form: solid
pka: -3.28±0.60(Predicted)
Appearance: White to off-white Solid
optical activity: [α]20/D +86°, c = 5.5 in methylene chloride
InChI: InChI=1S/C21H23NO4/c1-21(2,3)26-20(24)22-14-17(23)25-19(16-12-8-5-9-13-16)18(22)15-10-6-4-7-11-15/h4-13,18-19H,14H2,1-3H3/t18-,19+/m1/s1
InChIKey: MRUKRSQUUNYOFK-MOPGFXCFSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(=O)O[C@@H](C2=CC=CC=C2)[C@H]1C1=CC=CC=C1
CAS DataBase Reference: 112741-50-1(CAS DataBase Reference)

Less

Safety Information

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3

MSDS

Language:English Provider:SigmaAldrich

Less

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Usage And Synthesis

Uses

(2S,3R)-(+)-N-Boc-6-oxo-2,3-diphenylmorpholine (Williams chiral auxiliary) can be used as a reactant:

In the asymmetric synthesis of cylindrospermopsin and related alkaloids via an intramolecular 1,3-dipolar cycloaddition reaction.
To synthesize boc-3-(1-methylcyclopropyl)-D-alanine, which is used as an intermediate to prepare 4-fluoroproline-based analogs as potent tripeptide thrombin inhibitors.
In the total synthesis of potent hepatotoxic alkaloid 7-epicylindrospermopsin by intramolecular 1,3-dipolar cycloaddition and nitroaldol reaction.
To prepare differentially functionalized diaminoglutamic acids via radical reaction of selenide with methyl 2-acetamidoacrylate.

Synthesis

Tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate could be synthesize via a three-step procedure from erythro-2-amino-1,2-diphenylethanol

tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylateSupplier

Guangzhou Qianguang Trade Co., Ltd. Gold

Tel: 020-39071117 18030085485
Email: 2797782741@qq.com

Tianjin Derchemist Science & Technology Co., Ltd. Gold

Tel: 22-58627059 13920586291
Email: zdcomcon@126.com

ForeChem (Nantong) Technology Co.,Ltd. Gold

Tel: 513-85982855 18921614129
Email: sales@xianxingpharm.com

INTATRADE GmbH

Tel: +49 3493/605464
Email: sales@intatrade.de

Alfa Aesar

Tel: 400-6106006
Email: saleschina@alfa-asia.com

Less