RUFLOXACIN Chemical Properties

Boiling point:

574.6±50.0 °C(Predicted)

Density 

1.54

storage temp. 

2-8°C

pka

5.21±0.20(Predicted)

CAS DataBase Reference

101363-10-4

RUFLOXACIN Usage And Synthesis

Definition

ChEBI: Rufloxacin is a member of quinolines, a quinolone antibiotic and a fluoroquinolone antibiotic.

Pharmaceutical Applications

A tricyclic fluoroquinolone formulated as the hydrochloride salt. It is inactive against Gram-positive cocci with MICs >2 mg/L. It displays weak activity in vitro against Enterobacteriaceae with the MIC for most species >1 mg/L. Activity against Ps. aeruginosa is poor (MIC 16–32 mg/L). After loading doses of 400 and 600 mg followed with 9 days of either 200 or 300 mg, mean peak plasma levels were around 4.5–7 mg/L, respectively. The mean apparent elimination halflife was 44 h. Approximately 50% is eliminated in the urine.
It has been used in urinary tract infection and chronic prostatitis, but clinical experience is limited.

RUFLOXACIN(101363-10-4)Related Product Information

• Poly(hexamethylenebiguanide)hydrochloride
• Enoxacin
• Levofloxacin
• Ciprofloxacin hydrochloride
• rufloxacin sulfoxide
• RUFLOXACIN HCL,RUFLOXACIN HYDROCHLORIDE
• Rufloxacin 1-oxide
• RUFLOXACIN
• MF 961