4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL Chemical Properties

Melting point:

153-154 °C(Solv: acetic acid (64-19-7))

Boiling point:

472.9±40.0 °C(Predicted)

Density 

1.213±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO: >20mg/mL

form 

solid

pka

9.16±0.43(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-39

WGK Germany 

2

4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL Usage And Synthesis

Uses

VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].

References

[1] Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. DOI:10.1042/BJ20081424
[2] Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251. DOI:10.1074/jbc.C700175200

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