2-AMINO-3-NITRO-BENZALDEHYDE Chemical Properties

Melting point:

137-138 °C(Solv: methanol (67-56-1))

Boiling point:

335.8±32.0 °C(Predicted)

Density 

1.441±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-3.97±0.25(Predicted)

Appearance

Yellow to brown Solid

2-AMINO-3-NITRO-BENZALDEHYDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-amino-3-nitrobenzaldehyde from (2-amino-3-nitrophenyl)methanol: Synthesis of 6,7-didehydro-17-methyl-8'-nitroquinolo[2',3':6,7]morphinan-3,14β-diol hydrochloride (SYK-349) from compound 29d with reference to the procedure used for the preparation of SYK-27. The product is a brown amorphous solid with 98% yield and a melting point of 255-262°C (decomposition). Elemental analysis (C24H23N3O4-1.5HCl-0.5H2O) Calculated values: C, 59.91; H, 5.34; N, 8.73. Measured values: C, 60.10; H, 5.42; N, 8.46.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831

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