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Pirenzepine hydrochloride

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Pirenzepine hydrochloride Basic information

Product Name:
Pirenzepine hydrochloride
Synonyms:
  • Gasteril
  • Leblon
  • Maghen
  • Renzepin
  • Tabe
  • Ulcosan
  • Ulcuforton
  • 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-β][1,4]benzo- diazepin-6-one Dihydrochloride
CAS:
29868-97-1
MF:
C19H22ClN5O2
MW:
387.87
EINECS:
249-907-5
Product Categories:
  • Inhibitor
  • Intermediates & Fine Chemicals
  • All Inhibitors
  • Pharmaceuticals
  • Acetylcholine receptor
Mol File:
29868-97-1.mol
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Pirenzepine hydrochloride Chemical Properties

Melting point:
248-250°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble to 100 mM in water
Sensitive 
Hygroscopic
CAS DataBase Reference
29868-97-1(CAS DataBase Reference)
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Safety Information

WGK Germany 
2
RTECS 
UU7883000
HS Code 
2933.99.7500
Toxicity
dog,LD50,intravenous,62500ug/kg (62.5mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.

MSDS

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Pirenzepine hydrochloride Usage And Synthesis

Description

Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM). It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively). It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.

Chemical Properties

Solid

Originator

Microsules Bernabo, Microsules Bernabo

Uses

Antiulcerative;M1 antagonist

Uses

An antiulcerative. Tricyclic gastric-acid inhibitor.

Manufacturing Process

48.4 g of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo-diazepin-6-one were refluxed in 900 ml of absolute dioxane for 15 minutes. Thereafter, over a period of 45 minutes, 28 ml of chloroacetyl chloride and 52 ml of triethylamine were simultaneously added dropwise to the mixture. The mixture was refluxed for eight hours and then vacuum-filtered after having cooled. The filtrate was evaporated in vacuum. The crystalline residue was recrystallized from acetonitrile in the presence of activated charcoal. MP: 212°-213°C (with decomposition). Yield: 85% of theory.
A mixture of 67.5 g of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3b][1,4]benzodiazepin-6-one, 183 ml of N-methylpiperazine and 1.37 liters of absolute benzene was refluxed for 18 hours. Thereafter, the crystalline precipitate was vacuum filtered off, dissolved in aqueous 20% hydrochloric acid, the solution was evaporated in vacuum, the crystalline residue wasdissolved in 250 ml of water while heating, the solution was admixed with 150 ml of isopropanol and active charcoal, filtered, and 2.5 liters of isopropanol were added to the filtrate. After cooling, the precipitate was vacuum filtered off, yielding 70% of theory of the 5,11-dihydro-11-[(4'-methyl-1'-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride, M.P. 257259°C (decomp.).
The free base of pirenzepine, obtained from the dihydrochloride by making an aqueous solution thereof alkaline with dilute sodium hydroxide and extracting it with chloroform, had MP: 226°-228°C after recrystallization from methanol/ether.

Therapeutic Function

Antiulcer, Antiemetic

General Description

Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.

Biochem/physiol Actions

Selective M1 muscarinic acetylcholine receptor antagonist.

storage

Store at RT

Pirenzepine hydrochloride Preparation Products And Raw materials

Preparation Products

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