4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE Chemical Properties

Melting point:

270-273 °C(Solv: N,N-dimethylformamide (68-12-2))

Density 

1.79±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

4.50±1.00(Predicted)

Appearance

White to off-white Solid

4-CHLORO-5-HYDROXY-3(2H)-PYRIDAZINONE Usage And Synthesis

Uses

4-Chloro-5-hydroxy-3(2H)-pyridazine is an organic intermediate.

Synthesis

Wagner et al. reported that it can be prepared from 4,5-dichloropyridazin-3(2H)-one as starting material. 4,5-Dichloropyridazin-3(2H)-one (2 g, 12 mmol) was refluxed in 20 ml of 8N KOH for 6 hours. After acidification with HCl, the reaction mixture was concentrated in vacuum and extracted with ethyl acetate to give 4-chloro-5-hydroxy3(2H)-pyridazine. Yield 0.69 g, 54%. m.p. 267-272°C (from DMF), Lit. 270-273°C. IR: 2300-3340re,b,1650m,1595s,1555shcm-1.1H-NMR(DMSO-d6):δ=7.7 (s HatC-6),12.9(s,b,NH).C4H3C1N2O2(146.5);calcd.C32.78,H2.06,N19.12;foundC32.75,H2.17,N19.06.

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