5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties

Melting point:

74-77°

Boiling point:

203.7±40.0 °C(Predicted)

Density 

1.974±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

-1.47±0.22(Predicted)

form 

solid

color 

White

InChI

InChI=1S/C6H3F3IN/c7-6(8,9)5-2-1-4(10)3-11-5/h1-3H

InChIKey

GBAXFWLQMVBNMV-UHFFFAOYSA-N

SMILES

C1(C(F)(F)F)=NC=C(I)C=C1

Safety Information

HazardClass 

IRRITANT

HS Code 

2933998090

5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE Usage And Synthesis

Uses

5-Iodo-2-(trifluoromethyl)pyridine is a useful reactant for metal-catalyzed organic reactions.

Synthesis

Step 1: Synthesis of 5-iodo-2-(trifluoromethyl)pyridine 6-(Trifluoromethyl)pyridin-3-amine (9.96 g, 0.062 mol) was dissolved in 5N HCl (70 mL) and cooled to -5 °C. A 30 mL aqueous solution of sodium nitrite (6.39 g, 0.093 mol) was slowly added dropwise while keeping the internal temperature below 5 °C. After the dropwise addition, the reaction was continued at -5 °C for 10 min. Subsequently, a 30 mL aqueous solution of KI (22.5 g, 0.136 mol) was added slowly dropwise while keeping the internal temperature below 10 °C. After completion of the dropwise addition, the reaction mixture was gradually warmed up to room temperature. Extraction was carried out by adding 250 mL of EtOAc, and the pH of the aqueous layer was adjusted to 11 by adding 50 mL of 6N NaOH. the organic and aqueous layers were separated, and the organic layer was washed with 120 mL of 0.3 M Na2S2O3 solution. The EtOAc layer was concentrated and the resulting concentrate was purified by silica gel column chromatography (eluent: hexane/EtOAc = 25/1) to give the title compound as a white solid (14.6 g, 87% yield). MS (ESI) calculated value: C6H3F3IN [M]+: 273.0; measured value: 274.0 [M+H]+. 1H NMR (400 MHz, CDCl3) δ 8.96 (s, 1H), 8.22 (d, J = 8.2 Hz, 1H), 7.47 (d, J = 8.2 Hz, 1H).

References

[1] Patent: WO2015/187845, 2015, A1. Location in patent: Paragraph 0251
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0347
[3] Patent: WO2006/4533, 2006, A1. Location in patent: Page/Page column 25

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