2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Basic information
- Product Name:
- 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
- Synonyms:
-
- Rivaroxaban Impurity 10/4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
- 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]-
- 4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone
- 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione
- 2-[(2R)-2-hydroxy-3-{[4-(3-oxoMorpholin-4-yl)phenyl]aMino}p ropyl]-1H-isoindole-1,3(2H)-dione
- (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)-amino)propyl)isoindoline-1,3-dione
- Rivaroxaban interMediate B
- 2-[(2R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)anilino]propyl]isoindole-1,3-dione
- CAS:
- 446292-07-5
- MF:
- C21H21N3O5
- MW:
- 395.41
- EINECS:
- 610-200-5
- Product Categories:
-
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Intermediate of Rivaroxaban
- Mol File:
- 446292-07-5.mol
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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Chemical Properties
- Melting point:
- 208-211°C
- Boiling point:
- 734.9±60.0 °C(Predicted)
- Density
- 1.421
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 13.91±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 37mg/L at 20℃
- LogP
- 0.6 at 25℃
- CAS DataBase Reference
- 446292-07-5
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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Usage And Synthesis
Chemical Properties
White Solid
Uses
4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone is a Rivaroxaban (R538000(P)) intermediate. Rivaroxaban is a novel antithrombotic agent. It is also a highly potent and selective, direct FXa inhibitor.
Uses
Rivaroxaban intermediate.
Flammability and Explosibility
Non flammable
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dioneSupplier
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2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione(446292-07-5)Related Product Information
- 1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
- 2-QuinazolineMethanol, 4-Methyl-
- Rivaroxaban Impurity 34
- (R)-N-Glycidylphthalimide
- 4,5-DICHLOROTHIOPHENE-2-CARBOXYLIC ACID
- 2-Thiophenecarboxylic acid
- 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-
- Rivaroxaban
- POLYSTYRENE IODOSOACETATE
- 1,2-Cyclohexanedione
- (S)-(+)-Epichlorohydrin
- 4-(4-NITROPHENYL)MORPHOLIN-3-ONE
- (S)-(+)-Glycidyl Phthalimide
- 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one
- (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl
- 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
- 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]-