Triethylene Glycol 2-Bromoethyl Methyl Ether
Triethylene Glycol 2-Bromoethyl Methyl Ether Basic information
- Product Name:
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- Synonyms:
-
- Triethylene Glycol 2-Bromoethyl Methyl Ether
- m-PEG4-bromide
- Methyl-PEG4-bromide
- 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane
- Bromo-PEG4-methoxy
- 13-Bromo-2,5,8,11-tetraoxatridecane
- mPEG4-Br
- 2,5,8,11-Tetraoxatridecane, 13-bromo-
- CAS:
- 110429-45-3
- MF:
- C9H19BrO4
- MW:
- 271.15
- Mol File:
- 110429-45-3.mol
Triethylene Glycol 2-Bromoethyl Methyl Ether Chemical Properties
- Boiling point:
- 296.3±25.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- refractive index
- 1.4620 to 1.4660
- storage temp.
- 2-8°C
- form
- clear liquid
- color
- White to Yellow to Green
- CAS DataBase Reference
- 110429-45-3
Triethylene Glycol 2-Bromoethyl Methyl Ether Usage And Synthesis
Description
m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|