ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and proteins > Fmoc-norArg(pbf)-OH
Fmoc-norArg(pbf)-OH
Fmoc-norArg(pbf)-OH Basic information
- Product Name:
- Fmoc-norArg(pbf)-OH
- Synonyms:
-
- (2S)-4-[[amino-[(2,2,4,6,7-pentamethyl-3~{H}-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9~{H}-fluoren-9-ylmethoxycarbonylamino)butanoic acid
- (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}butanoic acid
- Fmoc-norArg(pbf)-OH
- Butanoic acid, 4-[[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-
- (2S)-4-[[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]butanoic acid
- (S,E)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(N'-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)formohydrazonamido)butanoic acid
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)butanoic acid
- (S)-2-(Fmoc-amino)-4-[[amino(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonamido)methylene]amino]butanoic Acid
- CAS:
- 1313054-32-8
- MF:
- C33H38N4O7S
- MW:
- 634.74
- Product Categories:
-
- amino acid
- amino acids
- Mol File:
- 1313054-32-8.mol
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Fmoc-norArg(pbf)-OH Chemical Properties
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.75±0.10(Predicted)
- InChIKey
- FWOIXFWITXCUKI-NDEPHWFRSA-N
- SMILES
- C(O)(=O)[C@@H](NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)CCNC=NNS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O
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Fmoc-norArg(pbf)-OH Usage And Synthesis
Chemical Properties
The IUPAC Name of Fmoc-norArg(pbf)-OH is rac-(R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)propanoic acid. Pbf is 2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl.
In addition, conjugation of Arg-containing peptides is difficult due to the steric hindrance of Pbf in a side chain as a protecting group, resulting in low peptide yield or even synthesis failure[1].
References
[1] Keiichi Yamada . “Efficient solid-phase synthesis of cyclic RGD peptides under controlled microwave heating.” Tetrahedron Letters 53 9 (2012): Pages 1066-1070.
Fmoc-norArg(pbf)-OHSupplier
Meryer (Shanghai) Chemical Technology Co., Ltd.
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- 021-61259108 18621169109
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Alabiochem Tech.Co., Ltd.
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- 512-58900862 400-0707518
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Shanghai Jian Chao Chemical Technology Co., Ltd.
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- 18017383231 18017383231
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Bide Pharmatech Ltd.
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- 400-164-7117 13681763483
- product02@bidepharm.com
Shanghai GL Peptide Ltd.
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- +86-21-61263340; 17609490614 13764994101
- fisherwang@glschina.com