Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Neuronal Signaling >  AChR antagonist >  (R)-5-HydroxyMethyl Tolterodine

(R)-5-HydroxyMethyl Tolterodine

Basic information Safety Supplier Related

(R)-5-HydroxyMethyl Tolterodine Basic information

Product Name:
(R)-5-HydroxyMethyl Tolterodine
Synonyms:
  • (R)-5-Hydroxymethyl tolterodine
  • 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol
  • R-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol
  • 5-hydroxyMethyl tolterodine (PNU 200577)
  • Desfesoterodine
  • PNU 200577
  • PNU-200577
  • (R)-2-(3-(diisopropylaMino)-1-phenylpropyl)-4-(hydroxyMethyl)phenol (5-HMT)
CAS:
207679-81-0
MF:
C22H31NO2
MW:
341.49
Product Categories:
  • Chiral Reagents
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
Mol File:
207679-81-0.mol
More
Less

(R)-5-HydroxyMethyl Tolterodine Chemical Properties

Melting point:
68-72°C
Boiling point:
490.7±45.0 °C(Predicted)
Density 
1.060±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.61±0.48(Predicted)
color 
Off-White to Pale Yellow
More
Less

(R)-5-HydroxyMethyl Tolterodine Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

(R)-5-HydroxyMethyl Tolterodine is a metabolite of Tolterodine (T535800), a muscarinic receptor antagonist used in the treatment of urinary incontinence.

Uses

A metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

Definition

ChEBI: Desfesoterodine is a diarylmethane.

in vivo

Desfesoterodine (PNU-200577; 5-Hydroxymethyl Tolterodine; 0.1 and 1 mg/kg; IV) significantly increases bladder compliance after moderate and high doses[4].
In vivo, Desfesoterodine is significantly more potent at suppressing acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50=15 and 40 nmol/kg, respectively) [1].

Animal Model:Female Sprague Dawley rats at ages 9 to 11 weeks weighing 180 to 250 g[4]
Dosage:0.1 and 1 mg/kg
Administration:IV; single imidafenacin administration
Result:Significantly increased bladder compliance after moderate and high doses.

(R)-5-HydroxyMethyl TolterodineSupplier

Olix (Shanghai) Pharmaceutical Technology Co., Ltd Gold
Tel
17316404525 17316404525
Email
209533805@qq.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
More
Less

(R)-5-HydroxyMethyl Tolterodine(207679-81-0)Related Product Information