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N-Boc-cis-4-Hydroxy-L-proline methyl ester

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N-Boc-cis-4-Hydroxy-L-proline methyl ester Basic information

Product Name:
N-Boc-cis-4-Hydroxy-L-proline methyl ester
Synonyms:
  • (2S,4S)-N-Boc-cis-4-hydroxy-L-proline methyl ester
  • N-Boc-cis-4-hydroxy-L-proline methyl ester, >97.0%(GC)
  • (2S,4S)-N-Boc-4-hydroxyproline methyl ester
  • 1-tert-butyl 2-methyl cis-4-hydroxypyrrolidine-1,2-dicarboxylate
  • cis-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • N-T-BOC-CIS-4-HYDROXY-L-PROLINE METHYL ESTER
  • N-ALPHA-T-BUTOXYCARBONYL-CIS-4-HYDROXY-L-PROLINE METHYL ESTER
  • N-Boc-cis-4-hydroxy-L-proline Methyl ester, 97%, 97%
CAS:
102195-79-9
MF:
C11H19NO5
MW:
245.27
EINECS:
627-146-3
Product Categories:
  • Heterocycles
  • Peptide Synthesis
  • Proline Derivatives
  • Unnatural Amino Acid Derivatives
Mol File:
102195-79-9.mol
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N-Boc-cis-4-Hydroxy-L-proline methyl ester Chemical Properties

Melting point:
82-86 °C (lit.)
Boiling point:
335.2±42.0 °C(Predicted)
Density 
1.216±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
14.27±0.40(Predicted)
form 
powder to crystal
color 
White to Almost white
optical activity
-63.6200°(C=1.011g/100ml ETOH)
Water Solubility 
Insoluble in water.
InChI
InChI=1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8-/m0/s1
InChIKey
SVSSZFBZFUSINI-SFYZADRCSA-N
SMILES
N1(C(OC(C)(C)C)=O)C[C@@H](O)C[C@H]1C(OC)=O
CAS DataBase Reference
102195-79-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36
WGK Germany 
2
HS Code 
29339900

MSDS

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N-Boc-cis-4-Hydroxy-L-proline methyl ester Usage And Synthesis

Chemical Properties

White solid

Uses

Used as a local anaesthetic. Used as therapeutic agents. Employed as important intermediates in various areas such as peptide synthesis, polymer chemistry..

Uses

2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester oline scaffold.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

IC 50

Non-cleavable Linker

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