(E)-4-Hydroxy-N-desmethyl Tamoxifen Chemical Properties

Melting point:

154-156°C

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White

InChI

InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+

InChIKey

MHJBZVSGOZTKRH-OCOZRVBESA-N

SMILES

C1(O)=CC=C(/C(/C2=CC=C(OCCNC)C=C2)=C(\C2=CC=CC=C2)/CC)C=C1

(E)-4-Hydroxy-N-desmethyl Tamoxifen Usage And Synthesis

Chemical Properties

White Solid

Uses

A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.

(E)-4-Hydroxy-N-desmethyl Tamoxifen(114828-90-9)Related Product Information

• (E/Z)-Tamoxifen
• N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
• Tamoxifen Impurity 3
• 4-Benzyloxy β-Hydroxy TaMoxifen
• TaMoxifen DiMer
• 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone
• N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture)
• 4Hydroxy Tamoxifen
• Tamoxifen EP Impurity D
• (E)-4-Alloxycarboxyl Tamoxifen
• desdimethyltamoxifen
• TAMOXIFEN-N-OXIDE
• Droloxifene
• (E)-4-Acetoxy Tamoxifen
• N-Desmethyl Tamoxifen Methanethiosulfonate
• 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine
• alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol
• Avacopan