LY2811376
LY2811376 Basic information
- Product Name:
- LY2811376
- Synonyms:
-
- LY2811376
- (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine
- LY 2811376,(4S)-4-[2,4-Difluoro-5-(5-pyriMidinyl)phenyl]-5,6-dihydro-4-Methyl-4H-1,3-thiazin-2-aMine
- CS-1893
- LY 2811376;LY-2811376
- (S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine
- (4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine
- N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl LY2811376
- CAS:
- 1194044-20-6
- MF:
- C15H14F2N4S
- MW:
- 320.36
- Product Categories:
-
- Inhibitor
- Inhibitors
- Mol File:
- 1194044-20-6.mol
LY2811376 Chemical Properties
- Boiling point:
- 486.5±55.0 °C(Predicted)
- Density
- 1.42
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 5.60±0.40(Predicted)
- color
- White to khaki
- InChI
- InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1
- InChIKey
- MJQMRGWYPNIERM-HNNXBMFYSA-N
- SMILES
- S1CC[C@](C2=CC(C3=CN=CN=C3)=C(F)C=C2F)(C)N=C1N
LY2811376 Usage And Synthesis
Uses
LY 281137 is a compound capable of the decrease in β-amyloid peptide (Aβ) associated with the cleavage of amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. This decrease is important as its hypothesized that the build up of (Aβ) in the brain is a primary cause of neurodegeneration and Alzheimer’s progression.
in vivo
LY2811376 (10, 30, and 100 mg/kg, p.o.) results in dose-dependent, significant reductions in Aβ as well as sAPPβ and C99, the proximal cleavage products of APP proteolysis by BACE1. LY2811376 produces dose-dependent decreases in all APP-related PD markers of BACE1 inhibition in PDAPP mice. Low (30 mg) and high (90 mg) doses of LY2811376 investigated in the CSF sampling study are based on PK and plasma Aβ1-40 PD observed in the SAD study[1]. LY2811376 (30 mg/kg, p.o.) can lead to a 60% decrease in the soluble Aβs in mouse cortex[2]. LY2811376 (100 mg/kg, p.o.) decreases the spine density and formation in mice. LY2811376 (100 mg/kg every 12 hours over 16 days) causes a reduction in the frequency of sEPSC and mEPSC, whereas the effects of LY2811376 on the amplitude of sEPSC fails to reach significance[4].
IC 50
BACE1
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