Fenbendazole-d3 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: slightly soluble,Methanol: slightly soluble

form 

Solid

color 

Off-white to light yellow

Safety Information

WGK Germany 

3

Fenbendazole-d3 Usage And Synthesis

Description

Fenbendazole-d₃ is intended for use as an internal standard for the quantification of fenbendazole by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC₅₀ = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.

Uses

Labelled Fenbendazole (F246750). An anthelmintic (Nematodes).

References

[1] U M MORGAN  R C T  J A Reynoldson. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1993, 37 2: 328-331. DOI: 10.1128/aac.37.2.328
[2] C. SUTER. Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole[J]. Veterinary Record, 2001, 16 1: 478-480. DOI: 10.1136/vr.148.15.478
[3] HOSSEIN ALEYASIN. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.[J]. Antioxidants & redox signaling, 2015, 22 2: 121-134. DOI: 10.1089/ars.2013.5595

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