Posaconazole-d4 Chemical Properties

Melting point:

170-172?C

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly, Heated)

form 

Solid

color 

Off-White to Light Grey

Stability:

Moisture Sensitive

Posaconazole-d4 Usage And Synthesis

Chemical Properties

Off-White Foam

Uses

Orally active labelled triazole antifungal.

Application

Posaconazole-d4, an isotope of posaconazole, was used as an internal standard and showed retention and ionization identical to those of posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.

General Description

This stable-labeled internal standard is suitable for quantification of posaconazole levels in blood, serum, or plasma by HPLC or LC-MS/MS. The antifungal posaconazole is used to treat invasive and systemic fungal infections. As a result of significant drug interactions, therapeutic drug monitoring of posaconazole is recommended when administered with protease inhibitors (PIs) or non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Liquid chromatography-mass spectrometry method for the quantification of posaconazole in human plasma: Application to pharmacokinetics following single-dose administration in the fasted state and with a high-fat meal

Posaconazole-d4(1133712-26-1)Related Product Information

• Posaconazole Impurity 49
• Posaconazole Impurity 44
• Posaconazole Impurity 17
• Posaconazole
• 1-((2S,3R)-2-(benzyloxy)pentan-3-yl)-N-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)hydrazine-1-carboxamide
• Posaconazole Diastereoisomer 11
• Posaconazole DiastereoisoMer interMediate 5
• 2,4-dihydro-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one
• Posaconazole DiastereoisoMer 2
• Posaconazole inter-8
• 4-(4-(4-(4-(((3S,5S)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
• Posaconazole iMpurity
• D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-
• 1,3-PROPANEDIOL, 2-[2-(2,4-DIFLUOROPHENYL)-2-PROPEN-1-YL]-
• Posaconazole Diastereoisomer 12
• Posaconazole DiastereoisoMer interMediate 2
• 1H-1,2,4-TRIAZOLE, 1-[[(2S)-2-(2,4-DIFLUOROPHENYL)OXIRANYL]METHYL]-
• Posaconazole-d5