LY-2608204 Chemical Properties

Density 

1.35

storage temp. 

Store at -20°C

solubility 

≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH

form 

solid

pka

8.17±0.70(Predicted)

color 

White to off-white

LY-2608204 Usage And Synthesis

Description

LY2608204 is an activator of glucokinase (GK; EC₅₀ = 42 nM). It stimulates glucose metabolism in INS-1E rat insulinoma cells (mean EC₅₀ = 579 nM). LY2608204 (30 mg/kg) decreases plasma glucose levels in a dose-dependent manner in fasted rats.

Uses

Globalagliatin (LY2608204) is an orally active glucokinase (GK) activator with an EC50 of 42 nM. Globalagliatin also stimulates glucose metabolism in rat insulinoma INS1-E cells with an EC50 of 579 nM. Globalagliatin targets both pancreatic β-cells and hepatocytes. Globalagliatin is promising for research of type 2 diabetes[1][2][3].

target

GK

References

[1] kj filipski, bd stevens . glucokinase activators in development .2012 books

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