Isoastilbin Chemical Properties

Melting point:

278-280 °C (decomp)

Boiling point:

801.1±65.0 °C(Predicted)

Density 

1.74±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

form 

Solid

pka

7.34±0.60(Predicted)

color 

White to off-white

InChIKey

ZROGCCBNZBKLEL-UQDOWIEGNA-N

SMILES

[C@@H]1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O)=C2)C(=O)[C@H]1OC1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 |&1:0,20,23,25,27,29,r|

CAS DataBase Reference

54081-48-0

Isoastilbin Usage And Synthesis

Description

Isoastilbin (IA) is a dihydroflavonol glycoside compound, and studies have shown that IA has a good effect on antioxidants.

Uses

Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research[1][21][3].

Biological Activity

Isoastilbin, a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. It inhibits glucosyltransferase (GTase) with IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. It has neuroprotective, antioxidant, antimicrobial and anti-apoptotic properties and can be used in Alzheimer's disease research.

target

References

[1] Hong Yu, et al. Protective Roles of Isoastilbin Against Alz heimer's Disease via Nrf2-mediated Antioxidation and anti?apoptosis. Int J Mol Med. 2019 Mar;43(3):1406-1416. DOI:10.3892/ijmm.2019.4058
[2] Harlinda Kuspradini, et al. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts. J. Wood Sci., 2009, 55(4):308-13.
[3] Batubara, Irmanida, et al. Anti-acne and Tyrosinase Inhibition Properties of Taxifolin and Some Flavanonol Rhamnosides from Kempas. Wood Research Journal ,2010, 1(1):45-9.

Isoastilbin(54081-48-0)Related Product Information

• Isochlorogenic acid C
• Neoastilbin
• Naringenin
• 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one
• hydroxygenkwanin
• (+/-)-TAXIFOLIN
• Quercetin-7-O-β-D-glucopyranoside
• GARDENIN B
• PONCIRIN
• MOSLOFLAVONE
• MEDICAGOL
• Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers)
• 4',5-DIHYDROXY-7-METHOXYFLAVONE
• Taxifolin
• TAXIFOLIN 3-O-RHAMNOSIDE
• ISOQUERCITRIN
• Isoacteoside
• Strictosidine