Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- Chemical Properties

Boiling point:

321.7±27.0 °C(Predicted)

Density 

1.350±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

14.36±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C8H17BrO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-8H2

InChIKey

CERQCRALBKUCTF-UHFFFAOYSA-N

SMILES

C(O)COCCOCCOCCBr

Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- Usage And Synthesis

Description

Bromo-PEG4-alcohol is a PEG linker containing a bromide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-(85141-94-2)Related Product Information

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