6-Azido-hexanoic acid Chemical Properties

Density 

1.074 g/mL

refractive index 

n/D 1.463

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless to Pale Yellow

Stability:

Light Sensitive

Safety Information

Safety Statements 

24/25

HS Code 

29270000

6-Azido-hexanoic acid Usage And Synthesis

Description

6-Azido-hexanoic acid is a linker containing an azide group and a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

Colorless to yellow oil

Uses

6-Azidohexanoic acid is a six-carbon saturated fatty acid with an ω-terminal azide group. This building block can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC), forming a stable amide bond. The terminal azide group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is useful for crosslinking, synthesis of chemical probes, and other bioconjugation strategies.

reaction suitability

reagent type: cross-linking reagent

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