6-bromo-3-methoxypyridin-2-amine Chemical Properties

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

Appearance

White to light brown Solid

Safety Information

HS Code 

2933399990

6-bromo-3-methoxypyridin-2-amine Usage And Synthesis

Synthesis

Step 2: Preparation of 6-bromo-3-methoxypyridin-2-amine A mixture of 6-bromo-3-methoxy-2-nitropyridine (14.4 g, 61.8 mmol), acetic acid (200 mL), and iron powder (14.0 g, 0.25 mol) was stirred and reacted at 90°C for 1.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with ethyl acetate. Subsequently, the mixture was filtered through diatomaceous earth and the filtrate was concentrated under vacuum. Purification by fast column chromatography using dichloromethane as eluent afforded the target compound 6-bromo-3-methoxypyridin-2-amine (10.2 g, 50.2 mmol) as a white solid.1H NMR (400 MHz, DMSO-d6) δ: 3.81 (s, 3H), 4.78 (br.s, 2H), 6.73 (d, J = 7.8 Hz 1H).

References

[1] Patent: WO2014/184234, 2014, A1. Location in patent: Page/Page column 63
[2] Patent: WO2014/6402, 2014, A1. Location in patent: Page/Page column 85

6-bromo-3-methoxypyridin-2-amine(916737-77-4)Related Product Information

• 6-bromo-3-chloro-2-fluorobenzaldehyde
• 2-AMino-6-broMonicotinic acid
• (6-aminopyridin-2-yl)methanol
• 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE
• 6-Methoxypyrazinamine
• 6-FLUOROQUINOLIN-2-AMINE
• 2-Amino-6-Iodobenzothiazole
• 6-BROMOBENZOXAZOLE
• ethyl 2-amino-6-chloroisonicotinate
• 2-amino-6-chloropyridine-4-carboxylic acid
• 2-Amino-6-chloro-3-pyridinecarboxaldehyde
• 2-Amino-6-trifluoromethylquinoxaline
• 2-AMINO-6-BROMOPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE
• 2-Amino-benzothiazole-6-carbonitrile
• 2-Amino-6-methylpyrazine
• 2-Amino-5-chloropyridine-3-carboxylic acid
• ETHYL 2-AMINO-6-CHLOROBENZOATE
• 2-Amino-6-bromo-pyridine-3-carbaldehyde