HO-PEG5-tBu Chemical Properties

Boiling point:

445.4±40.0 °C(Predicted)

Density 

1.071

refractive index 

n/D 1.448

storage temp. 

-20°C

form 

liquid

pka

14.36±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

HS Code 

2918999090

HO-PEG5-tBu Usage And Synthesis

Description

Hydroxy-PEG5-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

HO-PEG5-tBu(850090-09-4)Related Product Information

• Hydroxy-PEG4-methyl ester
• 4-MALEIMIDOBUTYRIC ACID
• 2-[2-(2-Azidoethoxy)ethoxy]ethanamine
• 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol
• 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
• 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester
• FMoc-NH-PEG9-CH2CH2COOH
• Decaethylene glycol
• FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID
• Biotin-PEG3-N3
• H2N-PEG4-tBu
• 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine
• Amino-PEG6-alcohol
• FMoc-NH-5(ethylene glycol)-acetic acid
• Fmoc-NH-PEG3-CH2COOH
• 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)-
• O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL)
• HS-PEG4-tBu