Sodium salicylate Chemical Properties

Melting point:

>300 °C (lit.)

Density 

0.32 g/cm3 (20℃)

storage temp. 

Store at +15°C to +25°C.

solubility 

1000g/l

form 

Crystals or Crystalline Powder

color 

White

PH

6.5 (100g/l, H2O, 20℃)

Odor

wh. lustrous cryst. scales or amorphous powd., odorless or faint odor, saline taste

Water Solubility 

1000 g/L (20 ºC)

Sensitive 

Light Sensitive

Merck 

14,8332

BRN 

3732792

Stability:

Stable. Incompatible with mineral acids, metallic salts, iodine. May be light-sensitive.

InChIKey

ABBQHOQBGMUPJH-UHFFFAOYSA-M

LogP

2.061 (est)

CAS DataBase Reference

54-21-7(CAS DataBase Reference)

EPA Substance Registry System

Sodium salicylate (54-21-7)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-41-36/37/38-36

Safety Statements 

26-36

WGK Germany 

1

RTECS 

VO5075000

F 

8

Autoignition Temperature

>250 °C

TSCA 

Yes

HS Code 

29182100

Toxicity

LD50 i.p. in rats: 780 mg/kg (Goldenthal)

MSDS

• Language:English Provider:2-Hydroxybenzoic acid sodium salt
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Sodium salicylate Usage And Synthesis

Description

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.

Chemical Properties

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.

Chemical Properties

Sodium salicylate, HOC6H4COONa, is a shiny, white powder with sweetish taste and mild aromatic aroma that is soluble in water,glycerol, and alcohol.Used in medicine and as a preservative.

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non - steroidal anti - inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultra violet radiation and electrons.

Uses

keratolytic

Uses

In manufacture of aspirin, methyl salicylate, and other salicylates. Coupling agent for azo dyes. Has been used as food preservative.

Definition

A salt or ester of salicylic acid.

brand name

Alysine (Marion Merrell Dow).

General Description

Sodium salicylate may be prepared by the reaction, in aqueoussolution, by adding equal molar ratio of salicylic acidand sodium bicarbonate; evaporating to dryness yields thewhite salt. In solution, particularly in the presence of sodiumbicarbonate, the salt will darken on standing. This is the saltof choice for salicylate medication and usually is administeredwith sodium bicarbonate to lessen gastric distress, or itis administered in enteric coated tablets. However, the useof sodium bicarbonate is ill advised, because it decreases theplasma levels of salicylate and increases the excretion offree salicylate in the urine.
Sodium salicylate, even though not as potent as aspirinfor pain relief, also has less GI irritation and is useful for patientswho are hypersensitive to aspirin.

Biochem/physiol Actions

Cell permeable: yes

Safety Profile

Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes: toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodme, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na2O.

Sodium salicylate(54-21-7)Related Product Information

• Sodium hydroxide
• Sodium 4-hydroxybenzoate
• Sodium benzoate
• Sodium bicarbonate
• Diclofenac sodium
• Methyl salicylate
• Salicylic acid
• P-AMINOSALICYLIC ACID SODIUM SALT
• Sodium citrate
• Trisodium phosphate
• Sodium acetate
• SALICYLIC ACID N-PROPYL ESTER
• 2-Cyanophenol
• 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
• Salicylaldoxime
• Benzyl salicylate
• AMMONIUM SALICYLATE
• 2-Hydroxyethyl salicylate
• Sodium Salicylate Solution