H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OH
H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OH Basic information
- Product Name:
- H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OH
- Synonyms:
-
- PKC SUBSTRATE PEPTIDE
- PROTEIN KINASE C SUBSTRATE PEPTIDE
- QKRPSQRSKYL
- MYELIN BASIC PROTEIN (4-14)
- MYELIN BASIC PROTEIN (4-14) (2)
- MYELIN BASIC PROTEIN (4-14) (BOVINE)
- MYELIN BASIC PROTEIN FRAGMENT 4-14
- L-Gln-L-Lys-L-Arg-L-Pro-L-Ser-L-Gln-L-Arg-L-Ser-L-Lys-L-Tyr-L-Leu-OH
- CAS:
- 126768-94-3
- MF:
- C60H103N21O17
- MW:
- 1390.59
- Product Categories:
-
- Peptide
- Myelin-Associated GlycoproteinEnzyme Substrates
- Protein Kinase C (PKC)Peptides for Cell Biology
- Protein Kinase CSerine/Threonine Kinase Biology
- Protein Kinase Related Peptides
- Protein Kinase Substrates
- Proteins and Derivatives
- Serine/Threonine Kinase Substrates
- Structural Proteins
- Substrates by Enzyme
- Mol File:
- 126768-94-3.mol
H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OH Chemical Properties
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- pka
- 3.37±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu
MSDS
- Language:English Provider:SigmaAldrich
H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OH Usage And Synthesis
Uses
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (Km=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts[1][2].
Biological Activity
Protein Target: PKC', 'Target Sub-Family: AGC
References
[1] Farrar YJ, et al. A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts. Biochem Biophys Res Commun. 1991;180(2):694-701. DOI:10.1016/s0006-291x(05)81121-0
[2] Yasuda I, et al. A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun. 1990;166(3):1220-1227. DOI:10.1016/0006-291x(90)90996-z
H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OHSupplier
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H-GLN-LYS-ARG-PRO-SER-GLN-ARG-SER-LYS-TYR-LEU-OH(126768-94-3)Related Product Information
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