ARRY-334543 Chemical Properties

Boiling point:

637.1±65.0 °C(Predicted)

Density 

1.51±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 50 mg/mL (107.08 mM; Need ultrasonic)

form 

Powder

pka

6.54±0.70(Predicted)

CAS DataBase Reference

845272-21-1

ARRY-334543 Usage And Synthesis

Uses

ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively.

Enzyme inhibitor

This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2.

target

ErbB2

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