(1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone Chemical Properties

Boiling point:

935.2±65.0 °C(Predicted)

Density 

1.39

storage temp. 

2-8°C

solubility 

DMSO: Soluble: = 10 mg/ml

pka

12.89±0.70(Predicted)

form 

solid

(1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone Usage And Synthesis

Uses

Withanoside V is a withanolide derivative isolated from the roots of Withania somnifera. Withania somnifera L. Dunal (Solanaceae), also known as ''ashwagandha'' in Sanskrit and as ''Indian ginseng'', is used widely in Ayurvedic medicine as a nerve tonic and memory enhancer, with antiaging, antistress, immunomodulatory and antioxidant properties.

References

[1] BOLLEDDULA JAYAPRAKASAM  Muraleedharan G N  Gale A Strasburg. Potent lipid peroxidation inhibitors from Withania somnifera fruits[J]. Tetrahedron, 2004, 60 13: Pages 3109-3121. DOI: 10.1016/j.tet.2004.01.016
[2] SHREYA DUBEY  Rajagopal S  Monika Kallubai. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives[J]. International Journal of Biological Macromolecules, 2021, 173: Pages 56-65. DOI: 10.1016/j.ijbiomac.2021.01.094
[3] RAJKUMAR SINGH KALRA. COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.[J]. Journal of Biomolecular Structure & Dynamics, 2022: 7885-7898. DOI: 10.1080/07391102.2021.1902858

(1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone(256520-90-8)Related Product Information

• 3-Methoxy-2, 3-dihydrowithaferin-A
• WITHANOLIDE B(P)(NEW)
• 4beta-Hydroxywithanolide E
• WITHANOSIDEIV
• Withania somnifera, ext.
• ASHWAGANDHA EXTRACT
• 6α-chloro-5β-hydroxywithaferin A
• WITHAFERIN A
• Withanolide C
• WITHANOLIDE A(P)
• 2,3-DIHYDROWITHAFERINA
• Withanolides
• WITHAFERIN A(P)
• (22R)-5β,6β-Epoxy-3-methoxy-1-oxo-4β,22,27-trihydroxyergost-24-en-26-oic acid 26,22-lactone
• Withaphysalin E
• (22R)-14,20,22-Trihydroxy-1-oxoergosta-2,5,24-triene-18,26-dioic acid 18,20:26,22-dilactone
• (13R,22R)-13,14:18,20-Diepoxy-14,18,22-trihydroxy-1-oxo-13,14-secoergosta-2,5,24-trien-26-oic acid 26,22-lactone
• WITHANOLIDE D(P)