H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 Chemical Properties

Density 

1.51±0.1 g/cm3(Predicted)

storage temp. 

-15°C

H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2 Usage And Synthesis

Uses

PKI(5-22)amide is the active inhibitory fragment of the inhibitor of the cyclic AMP-dependent protein kinase (PKA). PKI(5-22)amide inhibits PKA activation, but fails to attenuate homologous desensitization of CRF1 receptors[1][2].

References

[1] Dautzenberg FM, et al. GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation. Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46. DOI:10.1152/ajpregu.2001.280.4.R935
[2] Reed J, et al. Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J. 1989 Dec 1;264(2):371-80. DOI:10.1042/bj2640371

H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2(100853-58-5)Related Product Information

• H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-HIS-ASP-OH
• CAMP-DEPENDENT PROTEIN KINASE INHIBITOR (5-24) AMIDE
• PKA Inhibitor Fragment (6-22) amide
• H-THR-THR-TYR-ALA-ASP-PHE-ILE-ALA-SER-GLY-ARG-THR-GLY-ARG-ARG-ASN-ALA-ILE-NH2
• PROTEIN KINASE A INHIBITOR FRAGMENT 5-24 AMIDE TRIFLUOROACETATE SALT
• ASN-TYR-PRO-LEU-GLU-LEU-TYR-GLU-ARG-VAL-ARG-THR-GLY-CYS
• PROTEIN KINASE C (19-35)
• H-VAL-ARG-LYS-ARG-THR-LEU-ARG-ARG-LEU-OH
• H-ARG-PHE-ALA-ARG-LYS-GLY-SER-LEU-ARG-GLN-LYS-ASN-VAL-OH
• H-ARG-PHE-ALA-ARG-LYS-GLY-ALA-LEU-ARG-GLN-LYS-ASN-VAL-HIS-GLU-VAL-LYS-ASN-OH