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(2-Aminophenyl)dimethylphosphine Oxide

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(2-Aminophenyl)dimethylphosphine Oxide Basic information

Product Name:
(2-Aminophenyl)dimethylphosphine Oxide
Synonyms:
  • 2-(diMethylphosphoryl)aniline
  • 2-(diMethylphosphoryl)benzenaMine
  • (2-AMinophenyl)diMethylphosphine oxide
  • Benzenamine, 2-(dimethylphosphinyl)-
  • 2-(Dimethylphosphinyl)benzenamine
  • 2-(Dimethylphosphinyl)benzeneamine
  • 2-(Dimethylphosphinyl)aniline
  • 2-(diMethylphosphoryl)aniline HCl
CAS:
1197953-47-1
MF:
C8H12NOP
MW:
169.16
Mol File:
1197953-47-1.mol
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(2-Aminophenyl)dimethylphosphine Oxide Chemical Properties

Boiling point:
367.5±34.0 °C(Predicted)
Density 
1.11±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
1.10±0.10(Predicted)
InChI
InChI=1S/C8H12NOP/c1-11(2,10)8-6-4-3-5-7(8)9/h3-6H,9H2,1-2H3
InChIKey
DHHGHQKIKXKQGJ-UHFFFAOYSA-N
SMILES
C1(N)=CC=CC=C1P(C)(C)=O
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Safety Information

RIDADR 
UN2811
HS Code 
2923900090
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(2-Aminophenyl)dimethylphosphine Oxide Usage And Synthesis

Uses

(2-Aminophenyl)dimethylphosphine Oxide is mainly used as a raw material or reagent for organic synthesis and can be used to prepare other compounds such as phosphine oxide derivatives and pyrimidine derivatives.

Synthesis

(2-Aminophenyl)dimethylphosphine Oxide is prepared by the reaction of 2-Iodoaniline and Dimethylphosphine oxide. The specific synthesis steps are as follows:
To a solution of 2-iodoaniline ( 1.0 eq) and dimethylphosphine oxide (1.1 eq) in DMF were added potassium phosphate ( 1.1 eq) and palladium acetate/Xantphos (catalytic). The reaction was stirred at 150 °C for 3 hours and cooled to room temperature. The solvent was evaporated and the residue was worked up with DCM/water. The crude product was purified with a column(EtOAc/MeOH 10: 1 ) to give 1 as a brown solid (80percent yield).

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