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3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

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3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Basic information

Product Name:
3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester
Synonyms:
  • 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester
  • 1-Piperidinecarboxylic acid, 3,5-dioxo-, 1,1-diMethylethyl ester
  • tert-Butyl 3,5-dioxopiperidine-1-carboxylat
  • 5-dioxopiperidine-1-carboxylate
  • N-Boc-3,5-dioxopiperidine
  • 1-Piperidinecarboxylic acid, 3,5-dioxo-, 1,1-dimethylethyl e...
  • 1-Piperidinecarboxylic acid, 3,5-dioxo-, 1,1-dimethylethyl ester (9CI, ACI)
  • 3,5-dioxo-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)
CAS:
396731-40-1
MF:
C10H15NO4
MW:
213.23
Mol File:
396731-40-1.mol
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3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Chemical Properties

Boiling point:
346.2±32.0 °C(Predicted)
Density 
1.199±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
9.72±0.20(Predicted)
color 
Light yellow to yellow
CAS DataBase Reference
396731-40-1
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Safety Information

HS Code 
2933399990
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3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester Usage And Synthesis

Uses

3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


To a cooled (5 ??C) and stirred mixture of potassium 2-methyl-2-propoxide (29.7 g,0.27 mol) was added a solution of ethyl [A/-((1,1-dimethylethoxy)carbonyl),A/-(2-oxopropyl)]glycinate (65 g, 0.25 mol) in ethyl ether (200 ml) over a period of 1.5 h. The re- sulting mixture was stirred for an additional 3 h, and the formed precipitate was filtered offand washed with ethyl ether (2 x 100 ml). The solid was dissolved in water (150 ml), andacetic acid was added to adjust the pH to 4. The product was filtered, washed with water (2x 50 ml) and air dried to furnish 1 -[(1,1 -dimethylethoxy)carbonyl]-3,5-dioxopiperidine (28 g,52 %).>xxN'TOHPLC-MS: m/z: 158 (M+H-56).1H-NMR (DMSO-d6): 81.48 (9H, s), 4.03 (4H, s), 5.38 (1 H, s).

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