(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL CAS#: 3947-65-7

ChemicalBook > Product Catalog > Analytical Chemistry > Standard > Pharmaceutical Impurity Reference Standards > (1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL

Basic information Safety Supplier Related

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Basic information

Product Name:

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL

Synonyms:

5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
NEAMINE
U-5214
2-deoxy-4-o-(2,6-diamino-2,6-dideoxy-alpha-d-glucopyranosyl)-d-streptamin
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
5-amino-2-(aminomethyl)-6-(4,6-diamino-2,3-dihydroxycyclohexyl)oxyoxane-3,4-diol
dekamycinv
neamin

CAS:

3947-65-7

MF:

C12H26N4O6

MW:

322.36

Product Categories:

Intermediates

Mol File:

3947-65-7.mol

Less

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Chemical Properties

Melting point:: 225.5°C (rough estimate)
Boiling point:: 460.98°C (rough estimate)
alpha: D25+112.8° (c = 1)
Density: 1.1885 (rough estimate)
refractive index: 1.6120 (estimate)
storage temp.: Hygroscopic, Refrigerator, Under inert atmosphere
solubility: Aqueous Acid (Slightly), Methanol (Slightly, Heated), Water (Slightly)
pka: 13.24±0.70(Predicted)
form: Solid
color: White to Pale Yellow
Stability:: Hygroscopic
InChI: InChI=1/C12H26N4O6/c13-2-5-8(18)9(19)6(16)12(21-5)22-11-4(15)1-3(14)7(17)10(11)20/h3-12,17-20H,1-2,13-16H2/t3-,4+,5-,6-,7+,8-,9-,10-,11-,12-/s3
InChIKey: SYJXFKPQNSDJLI-CLPOQDAFNA-N
SMILES: [C@@H]1(O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O)[C@H](N)[C@@H](O)[C@H](O)[C@@H](CN)O1 |&1:0,2,3,6,8,10,12,14,16,18,r|

Less

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL Usage And Synthesis

Uses

Neamine is normally found as a core structure of aminoglycoside antibiotics. It is used in the synthesis of disaccharide neamine derivatives as antibacterial agents.

Definition

ChEBI: 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.

in vivo

Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts^[1].

Animal Model:	Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells^[1]
Dosage:	30 mg/kg, 60 mg/kg
Administration:	Subcutaneous injection; daily; for 14 days
Result:	Had anti-tumor effects on AsPC-1 xenograft models.

IC 50

Aminoglycoside

(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOLSupplier

RD International Technology Co., Limited Gold

Tel: 18024082417
Email: market@ubiochem.com

Guangzhou Younan Technology Co., Ltd Gold

Tel: 020-82000279 18988941452
Email: YN_research@163.com

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Email: sales@chemreagents.com

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Email: 3001272453@qq.com

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Email: sales@chem-strong.com

Less